Chris Lockhart, PhD
Research Assistant Professor
School of Systems Biology
George Mason University
Annuaire de GMULangues : Anglais (maternel), Français (DELF B2)
Expérience Professionnelle
George Mason University
Research Assistant Professor
School of Systems Biology • May 2021 – Aujourd'hui
Affiliate Faculty
School of Systems Biology • April 2018 – May 2021
Scratch Financial, Inc.
Manager, Data Science
March 2020 – April 2021
Sr. Data Scientist
April 2019 – March 2020
Aspiration Partners, Inc.
Data Scientist
April 2018 – April 2019
George Mason University
Postdoctoral Research Fellow
School of Systems Biology • January 2016 – March 2018
Adjunct Instructor
January 2016 – March 2018
Graduate Research Assistant
School of Systems Biology • February 2011 – December 2015
Formation
George Mason University
PhD, Bio-informatique et Biologie Computationnelle
2015
Virginia Tech
BS, Biological Sciences
BS, Psychology
2010
Mentorat
- • PhD Dissertation Chair (4 current students)
- • PhD Committee Member (8 current, 1 graduated)
- • Masters Thesis/Project Chair (4 current, 6 graduated)
- • Masters Committee Member (1 graduated)
- • ASSIP Mentor (6 previous interns)
- • Course Director for Young Scholars Program
Services et Responsabilités
University Service
- • Chair, College of Science Faculty Governance Nominations Committee (2025-2026)
- • Member, School of Systems Biology Bylaws Committee (2024-2026)
- • Member, College of Science Faculty Governance Nominations Committee (2024-2025)
- • Member, College of Science Dean's Award Nominations Committee (2023)
- • Curriculum Developer, BINF 761 (2025)
- • Curriculum Developer, BINF 735 (2023)
- • Administrator, Programming & Math Assessment for incoming graduate students (2023-Aujourd'hui)
- • Examiner, Systems Biology PhD Comprehensive Exam (2017-2021)
External Service
- • Reviewer, NIH DMPB Panel (2023)
- • Reviewer, Biology Direct, Computational and Structural Biotechnology Journal, Journal of Physical Chemistry B, Molecular Biology, Nature Computational Science
- • Blogger, Biophysical Society 61st Annual Meeting
- • Contributor, Programming expertise for the Aldrich Contemporary Art Museum (2020)
Prix et Distinctions
Dean's Research Support Award
College of Science, George Mason University
2022
Outstanding Doctoral Student Award
School of Systems Biology
2016
Impact Award
School of Systems Biology
2013
Outstanding Oral Aujourd'huiation
Student Research Day
2012
Outstanding Research Achievement
Bio-informatique et Biologie Computationnelle
2012
Navachat Tongvichit Memorial Award
School of Systems Biology
2011
Résumés Publiés
- • Xie, L., Lockhart, C., Klimov, D. K., & Jafri, M. S. (2026) Accurate prediction of cancer drug resistant variants using molecular simulation, machine learning, and network modeling. Biophys. J. 125(4): 23a.
- • Lockhart, C., Delfing, B. M., Laracuente, X. E., Olson, A., Luo, X., Jeffries, W., Foreman, K. W., Petruncio, G., Lee, K.-H., Paige, M., Kehn-Hall, K., & Klimov, D. K. (2025) Understanding the molecular mechanism of Venezuelan equine encephalitis virus inhibition. Biophys. J. 124(3): 220a.
- • Ganji, V. & Lockhart, C. (2024) Screening aggregation breakers of Alzheimer’s disease Aβ protofibrils using AutoDock CrankPep. J. Stud.-Sci. Res. 6, 4283.
- • Jain, S. & Lockhart, C. (2023) RexDash: A comprehensive dashboard for analyzing the technical performance of replica-exchange molecular dynamics simulations. J. Stud.-Sci. Res. 5, 3926.
- • Chawla, M. & Lockhart, C. (2023) De novo drug design for a protein binding site. J. Stud.-Sci. Res. 5, 3925.
- • Díaz Delgado, M. J. & Lockhart, C. (2023) Network analysis of replica exchange simulations. J. Stud.-Sci. Res. 5, 3924.
- • Gohil, K. & Lockhart, C. (2023) Binding of indolicin to the DMPC bilayer using molecular dynamics simulations. J. Stud.-Sci. Res. 5. 3923.
- • Goldberg, J. F., de Filippi, C. R., Lockhart, C., McNair, E. R., Sinha, S., Kong, H., Najjar, S. S., Lohmar, B. J., Tchoukina, I., Shah, K., Feller, E., Hsu, S., Rodrigo, M. E., Jang, M., Marboe, C., Berry, G. J., Valantine, H. A., Agbor-Enoh, S., Shah, P. (2023) Dysregulated circulating proteins in cellular and antibody-mediated rejection, on behalf of the GRAfT investigators. J. Heart Lung Transplant. 42(4): S67-S68.
- • Gohil, K. & Lockhart, C. (2022) Evaluating reduced and oxidized Aβ peptides using machine learning. J. Stud.-Sci. Res. 4., 3366.
- • Lockhart, C., Smith, A. K., & Klimov, D. K. (2020) Methionine oxidation alters the mechanism of Aβ interaction with DMPC bilayers. Biophys. J. 118(3): 61a.
- • Lockhart, C. & Klimov, D. K. (2017) Probing the binding of Aβ peptides to lipid bilayers. Biophys. J. 112(3): 364a.
- • Lockhart, C. & Klimov, D. K. (2015) Binding of Aβ monomer to DMPC bilayer using isobaric-isothermal replica-exchange molecular dynamics. Biophys. J. 108(2): 64a-65a.
- • Lockhart, C. & Klimov, D. K. (2013) Binding of FDDNP biomarker to Alzheimer's disease Aβ peptide. Biophys. J. 104(2): 360a.
Présentations
- • Xie, L., Lockhart, C., Klimov, D. K., & Jafri, M. S. "Accurate prediction of cancer drug resistant variants using molecular simulation, machine learning, and network modeling." Biophysical Society 70th Annual Meeting, San Francisco, CA, February 2026. (Poster).
- • Han, Y., Sealey, L., Fu, Y., Chilin, L., Tiwari, S., Lockhart, C., Delfing, B. M., Jafri, M. S., Klimov, D. K., & Wu, Y. "The decameric repeat of PSGL-1 functions as a basic antiviral unit in restricting HIV-1 infectivity." Retroviruses 50th Annual Meeting, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, May 2025 (Talk presented by Y. Han and B. M. Delfing).
- • Han, Y., Sealey, L., Fu, Y., Chilin, L., Tiwari, S., Lockhart, C., Delfing, B. M., Jafri, M. S., Klimov, D. K., & Wu, Y. "The decameric repeat of PSGL-1 functions as a basic antiviral unit in restricting HIV-1 infectivity." HIV Dynamics and Replication Program 28th Think Tank Meeting, National Cancer Institute, Frederick, MD, April 2025 (Talk presented by Y. Han and B. M. Delfing).
- • Tiwari, S., Delfing, B. M., Han, Y., Lockhart, C., Haikerwal, A., Jafri, M. S., Klimov, D. K., & Wu, Y. "PSGL-1 excludes HIV Env from virion surface through spatial hindrance involving structural folding of the decameric repeats." HIV Dynamics and Replication Program 28th Think Tank Meeting, National Cancer Institute, Frederick, MD, April 2025 (Talk presented by S. Tiwari and B. M. Delfing).
- • Lockhart, C., Delfing, B. M., Laracuente, X. E., Olson, A., Luo, X., Jeffries, W., Foreman, K. W., Petruncio, G., Lee, K.-H., Paige, M., Kehn-Hall, K., & Klimov, D. K. "Understanding the molecular mechanism of Venezuelan equine encephalitis virus inhibition." Biophysical Society 69th Annual Meeting, Los Angeles, CA, February 2025. (Poster).
- • Ganji, V. & Lockhart, C. "Screening aggregation breakers of Alzheimer's disease Aβ protofibrils using AutoDock CrankPep." Aspiring Scientists Summer Internship Program Research Celebration, George Mason University, Manassas, VA, August 2024 (Poster presented by V. Ganji).
- • Díaz Delgado, M. J. & Lockhart, C. "Network analysis of replica exchange simulations." Aspiring Scientists Summer Internship Program Research Celebration, George Mason University, Manassas, VA, August 2023 (Poster presented by M. Díaz Delgado).
- • Jain, S. & Lockhart, C. "RexDash: A comprehensive dashboard for analyzing the technical performance of replica-exchange molecular dynamics simulations." Aspiring Scientists Summer Internship Program Research Celebration, George Mason University, Manassas, VA, August 2023 (Poster presented by S. Jain).
- • Chawla, M. & Lockhart, C. "De novo drug design for a protein binding site." Aspiring Scientists Summer Internship Program Research Celebration, George Mason University, Manassas, VA, August 2023 (Poster presented by M. Chawla).
- • Gohil, K. & Lockhart, C. "Binding of indolicidin to the DMPC bilayer using molecular dynamics simulations." Aspiring Scientists Summer Internship Program Research Celebration, George Mason University, Manassas, VA, August 2023 (Poster presented by K. Gohil).
- • Goldberg, J. F., de Filippi, C. R., Lockhart, C., McNair, E. R., Sinha, S., Kong, H., Najjar, S. S., Lohmar, B. J., Tchoukina, I., Shah, K., Feller, E., Hsu, S., Rodrigo, M. E., Jang, M., Marboe, C., Berry, G. J., Valantine, H. A., Agbor-Enoh, S., & Shah, P. "Dysregulated circulating proteins in cellular and antibody-mediated rejection, on behalf of the GRAfT Investigators." ISHLT 43rd Annual Meeting, Denver, CO, April 2023 (Talk presented by J. F. Goldberg).
- • Gohil, K. & Lockhart, C. "Evaluating reduced and oxidized Aβ peptides using machine learning." Aspiring Scientists Summer Internship Program Research Celebration, George Mason University, Manassas, VA, August 2022 (Talk presented by K. Gohil).
- • Lockhart, C., Smith, A. K., & Klimov, D. K. "Methionine oxidation alters the mechanism of Aβ interaction with DMPC bilayers." Biophysical Society 64th Annual Meeting, San Diego, CA, February 2020. (Poster).
- • Lockhart, C. & Klimov, D. K. "Probing the binding of Aβ peptides to lipid bilayers." Biophysical Society 61st Annual Meeting, New Orleans, LA, February 2017. (Poster).
- • Lockhart, C. & Klimov, D. K. "Binding of Aβ monomer to DMPC bilayer using isobaric-isothermal replica-exchange molecular dynamics." Biophysical Society 59th Annual Meeting, Baltimore, MD, February 2015. (Poster).
- • Lockhart, C. "Molecular dynamics simulations of peptides relevant to Alzheimer's disease." Colloquia of Computational Materials Science Center, George Mason University, Fairfax, VA, October 2015. (Invited talk).
- • Lockhart, C. & Klimov, D. K. "Binding of Aβ to DMPC bilayer." Student Research Day, School of Systems Biology, George Mason University, Manassas, VA, December 2014. (Oral presentation).
- • Lockhart, C. & Klimov, D. K. "Binding of FDDNP biomarker to Alzheimer's disease Aβ peptide." Biophysical Society 57th Annual Meeting, Philadelphia, PA, February 2013. (Oral presentation).
- • Lockhart, C. & Klimov, D. K. "Binding of FDDNP biomarker to Alzheimer's disease Aβ peptide." Student Research Day, School of Systems Biology, George Mason University, Manassas, VA, December 2012. (Award-winning oral presentation).
Voir Toutes Les Publications
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